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Effects of treatment sequences for obesity management on bone metabolism need to be evaluated as obesity is a chronic disease requiring different sequences of treatment such as calorie restriction, bariatric/metabolic surgery, and anti-obesity drugs
Even patients who weren't at goal on another GLP-1 agonist have seen additional weight loss and blood sugar control when switching to tirzepatide
Under cholesterol stimulation, EX-4 and AICAR increased the ratio of p-AMPK/AMPK, ABCA1 protein levels, and cell viability, which were further promoted by their co-treatment (Figures 2B,C)
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